Edited by Zoran Mandić
ISBN: 978-953-56942-1-2
© 2014 by the authors; licensee IAPC, Zagreb, Croatia.
This book is an open-access book distributed under the terms and conditions of the Creative Commons Attribution license.
DOI: 10.5599/obp.7.0

Physico-Chemical Methods in Drug Discovery and Development

by Zoran Mandić

Improving human health and preventing illness and various diseases is one of the major areas of human endeavour in contemporary science. Huge amounts of money are invested in drug research both in academic institutions and pharmaceutical companies. Discovery of new biologically active chemical entities, their promotion in clinical candidates and drug molecules, as well as design of efficient drug formulations and their improvement are long-term tasks requiring a multi-disciplinary approach. Throughout the research process scientists are faced with challenges where important decisions have to be made and crucial actions have to be taken in order to keep pace with ever-increasing demands from the pharmaceutical market and pharmaceutical management.

Physical chemistry underlies most of the tools that medicinal chemists have at hand to assist them in their research. The vast armada of physico-chemical methods and techniques available enable fast and accurate measurements of specific parameters facilitating identification and selection of drug candidates. However, appropriate applications of physico-chemical techniques or their combinations, the proper choice of the corresponding methods as well as accurate interpretation of the results relies not only on good knowledge of physical chemistry but also on open and active communication between scientists of various backgrounds.

This book gives a selection of topics related to the various methods commonly used in pharmaceutical research. The intention, on the one hand, is to provide a theoretical background of the particular technique in order to enable inexperienced readers to gain a general impression of the usefulness of the field. On the other hand, a lot of practical examples will provide scientists, who encounter these methods either in the pharmaceutical research process or in academic institutions, with enough useful information for the successful application of these methods in their everyday work.

Chapter 1. Physicochemical Profiling in Drug Research and Development Download
by Krisztina Takács-Novák
DOI number: 10.5599/obp.7.1
Downloaded: 61
Chapter 2. Application of High Performance Liquid Chromatography for the Measurements of Lipophilicity and Biomimetic Binding Properties in Drug Discovery Download
by Klara Valko
DOI number: 10.5599/obp.7.2
Downloaded: 28
Chapter 3. The Importance of and Different Approaches to Permeability Determination Download
by Kin Tam, Matěj Velický, Robert Dryfe
DOI number: 10.5599/obp.7.3
Downloaded: 30
Chapter 4. Protein-Ligand Interactions Download
by Geoff Holdgate
DOI number: 10.5599/obp.7.4
Downloaded: 34
Chapter 5. NMR Spectroscopy for Studying Interactions of Bioactive Molecules Download
by Predrag Novak, Tomislav Jednačak
DOI number: 10.5599/obp.7.5
Downloaded: 11
Chapter 6. Chiral Separation for Enantiomeric Determination in the Pharmaceutical Industry Download
by Nelu Grinberg, Su Pan
DOI number: 10.5599/obp.7.6
Downloaded: 11
Chapter 7. The Importance of Choosing the Optimal Solid Form of a Drug Download
by Rolf Hilfiker
DOI number: 10.5599/obp.7.7
Downloaded: 24
Chapter 8. Thermal Analysis and Calorimetric Methods Applied to Pharmaceutical Solid Forms Download
by Danièle Giron
DOI number: 10.5599/obp.7.8
Downloaded: 19
Chapter 9. Near Infrared Spectroscopy in Drug Discovery and Development Processes Download
by Yves Roggo, Klara Dégardin, Michel Ulmschneider
DOI number: 10.5599/obp.7.9
Downloaded: 22
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